Journal article

White matter integrity alternations associated with cocaine dependence and long-term abstinence: Preliminary findings

Qinghua He, Dandan Li, Ofir Turel, Antoine Bechara, Yih-Ing Hser

BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2020

Abstract

Cocaine dependence has been associated with deficits in white matter (WM) integrity. Nevertheless, what happens to WM integrity after long-term abstinence is not fully understood. To bridge this gap, changes in WM integrity were examined with diffusion tensor imaging (DTI) applied to 39 participants: 12 participants who used cocaine in the last year (CURRENT USERS), 20 who were at different stages of cocaine abstinence (ABSTINENCE) [five with 1-5 years of abstinence (ABS1), five with 6-10 years of abstinence (ABS2), and 10 with over 10 years of abstinence (ABS3)], and 7 healthy controls (CONTROLS). The CONTROL group had higher fractional anisotropy (FA) compared to CURRENT USERS in frontal c..

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Grants

Awarded by National Institute on Drug Abuse (NIDA)


Awarded by National Natural Science Foundation of China


Awarded by Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars


Awarded by Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences


Awarded by High-end Foreign Expert Introduction Program


Funding Acknowledgements

YH was supported by National Institute on Drug Abuse (NIDA), Grants R03DA032542-01A1 and P30DA016383. QH was supported by research grants from the National Natural Science Foundation of China (31972906), Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars (cx2017049), Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences (KLMH2019K05), and the High-end Foreign Expert Introduction Program (G20190022029). We would also like to thank Alexandra Hollihan and Stephanie Castillo who helped with the data collection.