Journal article
White matter integrity alternations associated with cocaine dependence and long-term abstinence: Preliminary findings
Qinghua He, Dandan Li, Ofir Turel, Antoine Bechara, Yih-Ing Hser
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2020
Abstract
Cocaine dependence has been associated with deficits in white matter (WM) integrity. Nevertheless, what happens to WM integrity after long-term abstinence is not fully understood. To bridge this gap, changes in WM integrity were examined with diffusion tensor imaging (DTI) applied to 39 participants: 12 participants who used cocaine in the last year (CURRENT USERS), 20 who were at different stages of cocaine abstinence (ABSTINENCE) [five with 1-5 years of abstinence (ABS1), five with 6-10 years of abstinence (ABS2), and 10 with over 10 years of abstinence (ABS3)], and 7 healthy controls (CONTROLS). The CONTROL group had higher fractional anisotropy (FA) compared to CURRENT USERS in frontal c..
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Awarded by National Institute on Drug Abuse (NIDA)
Awarded by National Natural Science Foundation of China
Awarded by Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars
Awarded by Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Awarded by High-end Foreign Expert Introduction Program
Funding Acknowledgements
YH was supported by National Institute on Drug Abuse (NIDA), Grants R03DA032542-01A1 and P30DA016383. QH was supported by research grants from the National Natural Science Foundation of China (31972906), Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars (cx2017049), Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences (KLMH2019K05), and the High-end Foreign Expert Introduction Program (G20190022029). We would also like to thank Alexandra Hollihan and Stephanie Castillo who helped with the data collection.