Journal article

Decision Making Deficits in Relation to Food Cues Influence Obesity: A Triadic Neural Model of Problematic Eating

Rui Chen, Danni P Li, Ofir Turel, Thomas A Sorensen, Antoine Bechara, Yonghui Li, Qinghua He

FRONTIERS IN PSYCHIATRY | FRONTIERS MEDIA SA | Published : 2018

Abstract

In this review article we propose a model of the brain systems, the deficiency of which may underlie problematic eating. This integrative model is based on studies that have focused on discrete brain components involved in problematic eating, combined with insights from studies on the neurocognitive basis of other addictive and problematic behaviors. The model includes: (a) a hyper-functioning reward anticipation and processing system (amygdala-striatum dependent) in response to food-related cues; (b) a hypo-functioning reflective and inhibitory control system (prefrontal cortex dependent), that fails to anticipate and properly weigh future outcomes; and (c) an altered interoceptive awarenes..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars


Awarded by Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences


Awarded by Fundamental Research Funds for Central Universities


Funding Acknowledgements

QH was supported by research grants from the National Natural Science Foundation of China (31400959), Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars (cx2017049), Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences (KLMH2015G01), and Fundamental Research Funds for Central Universities (SWU1809003 and SWU1709106). TS was supported by the Independent Research Fund Denmark.