Journal article

Differential Impact of Mitral Valve Repair on Outcome of Coronary Artery Bypass Grafting with or without Surgical Ventricular Reconstruction in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial

Michael YC Tsang, Lilin She, Fletcher A Miller, Jin-Oh Choi, Robert E Michler, Paul A Grayburn, Robert O Bonow, Lorenzo Menicanti, Marek A Deja, Serenella Castelvecchio, Vivek Rao, Peter K Smith, Tomasz Kukulski, George Sopko, David L Prior, Eric J Velazquez, Kerry L Lee, Jae K Oh

STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

Background: This study examined the impact of mitral valve repair (MVRe) on survival of patients with moderate or severe (≥2+) MR and ischemic cardiomyopathy randomized to coronary artery bypass grafting (CABG) versus CABG+surgical ventricular reconstruction (SVR) in the STICH trial. Methods: Among patients with moderate or severe MR and ischemic cardiomyopathy undergoing CABG or CABG+SVR, the impact of MVRe on mortality between the two treatment arms was compared. Results: Among 867 patients with assessment of baseline MR severity, 211 had moderate or severe MR. After excluding 7 patients who underwent mitral valve replacement, 50, 44, 62, and 48 patients underwent CABG, CABG+MVRe, CABG+SVR..

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Grants

Awarded by National Heart, Lung, and Blood Institute/National Institutes of Health


Funding Acknowledgements

This work was supported by grants U01-HL69015, U01-HL69013, and R01-HL10583 from the National Heart, Lung, and Blood Institute/National Institutes of Health. The views expressed in this manuscript do not necessarily reflect those of the NHLBI or the NIH.