Fructose Metabolism and Cardiac Metabolic Stress
M Annandale, LJ Daniels, X Li, JPH Neale, AHL Chau, HA Ambalawanar, SL James, P Koutsifeli, LMD Delbridge, KM Mellor
FRONTIERS IN PHARMACOLOGY | FRONTIERS MEDIA SA | Published : 2021
Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and cardiovascular disease. Serum and cardiac tissue fructose levels are elevated in diabetic patients, and cardiac production of fructose via the intracellular polyol pathway is upregulated. The question of whether direct myocardial fructose exposure and upregulated fructose metabolism have potential to induce cardiac fructose toxicity in metabolic stress settings arises. Unlike tightly-regulated glucose metabolism, fructose bypasses the rate-limiting glycolytic enzyme, phosphofructokinase, and proceeds through glycolysis in an unregulated ..View full abstract
Awarded by Health Research Council of New Zealand
This work is supported by the Health Research Council of New Zealand (16/300) and the Maurice Wilkins Centre for Molecular Biodiscovery.