Journal article
The Role of Glucose Transporters in Oral Squamous Cell Carcinoma
Heinrich Botha, Camile S Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
BIOMOLECULES | MDPI | Published : 2021
DOI: 10.3390/biom11081070
Abstract
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy associated with a poor prognosis. The Warburg effect can be observed in OSCCs, with tumours requiring a robust glucose supply. Glucose transporters (GLUTs) and sodium-glucose co-transporters (SGLTs) are overexpressed in multiple malignancies, and are correlated with treatment resistance, clinical factors, and poor overall survival (OS). We conducted a systematic review to evaluate the differences in GLUT/SGLT expression between OSCC and normal oral keratinocytes (NOK), as well as their role in the pathophysiology and prognosis of OSCC. A total of 85 studies were included after screening 781 papers. GLUT-1 is regularly expressed in..
View full abstractGrants
Funding Acknowledgements
This work was supported by the University of Melbourne-"NOEL ARTHUR TWISS" scholarship. The authors would like to thank Jim Berryman, Liaison Librarian, Brownless Biomedical Library, University Library, The University of Melbourne, for his support with developing the search strategy for this systematic review.