Journal article

Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe

Julia Schneider, Bernd Hoffmann, Cristina Fevola, Marie Luisa Schmidt, Christian Imholt, Stefan Fischer, Frauke Ecke, Birger Hoernfeldt, Magnus Magnusson, Gert E Olsson, Annapaola Rizzoli, Valentina Tagliapietra, Mario Chiari, Chantal Reusken, Elena Buzan, Maria Kazimirova, Michal Stanko, Thomas A White, Daniela Reil, Anna Obiegala Show all

VIRUSES-BASEL | MDPI | Published : 2021

Abstract

The development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (Myodes glareolus, syn. Clethrionomys glareolus). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles (Myodes rutilus, syn. Cl..

View full abstract

University of Melbourne Researchers

Grants

Awarded by EU


Awarded by German Federal Ministry of Education and Research (BMBF)


Awarded by Federal Environment Agency (UBA) within the Environment Research Plan of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU)


Awarded by VINNOVA


Awarded by Swedish Research Council Formas


Awarded by Swiss National Science Foundation


Funding Acknowledgements

The investigations were partly funded by EU grant FP7-261504 EDENext (awarded to R.G.U., A.R., V.T., H.C.H. and H.H.), by the German Federal Ministry of Education and Research (BMBF) through the German Research Platform for Zoonoses ("NaUPa-net", FKZ 01KI1018 and 01KI1303) and partly commissioned and funded by the Federal Environment Agency (UBA) within the Environment Research Plan of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU) (grant number 3709 41 401 and grant number 3713 48 401 awarded to J.J.). Sampling of bank voles in Sweden was mainly funded by grants to B.H. (Birger Hornfeldt) and F.E. from the Swedish Environmental Protection Agency (via the National Environmental Monitoring Programme), Alvins' fund, Stiftelsen Oscar och Lili Lamms Minne, VINNOVA (P32060-1), and the Swedish Research Council Formas (2007-107). G.H. was supported by the Swiss National Science Foundation (grant 31003A-176209). Sampling in Italy was supported by the Fondazione E. Mach (C.F., A.R., V.T., H.C.H.). The contents of this publication are the sole responsibility of the authors and do not necessarily reflect the views of the European Commission.