Journal article

High-frequency rTMS over the dorsolateral prefrontal cortex on chronic and provoked pain: A systematic review and meta-analysis

Xianwei Che, Robin FH Cash, Xi Luo, Hong Luo, Xiaodong Lu, Feng Xu, Yu-Feng Zang, Paul B Fitzgerald, Bernadette M Fitzgibbon

BRAIN STIMULATION | ELSEVIER SCIENCE INC | Published : 2021

Abstract

BACKGROUND: High-frequency rTMS over the dorsolateral prefrontal cortex (DLPFC) has demonstrated mixed effects on chronic and provoked pain. OBJECTIVES/METHODS: In this study, a meta-analysis was conducted to characterise the potential analgesic effects of high-frequency rTMS over the DLPFC on both chronic and provoked pain. RESULTS: A total of 626 studies were identified in a systematic search. Twenty-six eligible studies were included for the quantitative review, among which 17 modulated chronic pain and the remaining investigated the influence on provoked pain. The left side DLPFC was uniformly targeted in the chronic pain studies. While our data identified no overall effect of TMS across..

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University of Melbourne Researchers

Grants

Awarded by National Natural Science Foundation of China


Awarded by Provincial Advantage Discipline Project


Awarded by NHMRC Practitioner Fellowship


Awarded by Australian Research Council


Awarded by Key Project of the Department of Science and Technology of Zhejiang Province


Funding Acknowledgements

XC is supported by the National Natural Science Foundation of China (4045F41120040) , and Provincial Advantage Discipline Project (20JYXK034) . PF is supported by an NHMRC Practitioner Fellowship (606907) , and RFHC is supported by the Australian Research Council (DE200101708) . YZ is supported by Key Project of the Department of Science and Technology of Zhejiang Province (2015C03037) . The authors declare no competing financial interests.