Journal article

Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review

Sheliza Halani, Panashe E Tombindo, Ryan O'Reilly, Rafael N Miranda, Laura K Erdman, Clare Whitehead, Joanna M Bielecki, Lauren Ramsay, Raphael Ximenes, Justin Boyle, Carsten Krueger, Shannon Willmott, Shaun K Morris, Kellie E Murphy, Beate Sander

PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

BACKGROUND: Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth defects amongst children born to infected pregnant women, as well as increases in neurological manifestations in adults has been demonstrated. We systemically reviewed the literature to understand clinical manifestations and health outcomes in adults globally. METHODS: This review was registered prospectively with PROPSERO (CRD 42018096558). We systematically searched for studies in six database..

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