Journal article

Adding saliva testing to oropharyngeal and deep nasal swab testing increases PCR detection of SARS-CoV-2 in primary care and children

Jane Oliver, Shidan Tosif, Lai-Yang Lee, Anna-Maria Costa, Chelsea Bartel, Katherine Last, Vanessa Clifford, Andrew Daley, Nicole Allard, Catherine Orr, Ashley Nind, Karyn Alexander, Niamh Meagher, Michelle Sait, Susan A Ballard, Eloise Williams, Katherine Bond, Deborah A Williamson, Nigel W Crawford, Katherine B Gibney



OBJECTIVE: To compare the concordance and acceptability of saliva testing with standard-of-care oropharyngeal and bilateral deep nasal swab testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in children and in general practice. DESIGN: Prospective multicentre diagnostic validation study. SETTING: Royal Children's Hospital, and two general practices (cohealth, West Melbourne; Cirqit Health, Altona North) in Melbourne, July-October 2020. PARTICIPANTS: 1050 people who provided paired saliva and oropharyngeal-nasal swabs for SARS-CoV-2 testing. MAIN OUTCOME MEASURES: Numbers of cases in which SARS-CoV-2 was detected in either specimen type by real-time polymerase chain reac..

View full abstract