Journal article

Associations between body mass index and the surgical phenotype and location of endometriotic lesions

Katherine A Enright, Sandra Louise, Uri P Dior, Martin Healey, Sarah J Holdsworth-Carson



RESEARCH QUESTION: Is there a relationship between body mass index (BMI) and endometriotic lesions, specifically surgical phenotype and lesion location? DESIGN: An observational retrospective cohort study at the Royal Women's Hospital, Melbourne, Australia, including 471 histologically confirmed endometriosis patients. Statistical analyses included multivariate logistic regression and multivariate modelling, correcting for multiple testing. Outcomes were the presence or absence of surgically classified lesion phenotypes, as per revised American Society for Reproductive Medicine criteria including superficial or deep, peritoneal or ovarian, and adhesions (Study I); and lesions at specific ana..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

\We would like to thank Professor Peter Rogers (Department of Obstetrics and Gynecology, University of Melbourne/Royal Women's Hospital) and Dr Jane Girling (Department of Anatomy, Otago University) for their critical evaluation of this manuscript. We also acknowledge the assistance of Ms Melissa Parker and Associate Professor Boon Lim (Canberra Hospital) for their joint supervision of KAE. We also thank Professor Peter Rogers, Dr Jane Girling and Professor Grant Montgomery (Institute for Molecular Bioscience, University of Queensland) for funding support in establishing the endometriosis tissue bank (Protocol 10/43). We would like to thank Ms Leonie Cann for assistance with organising the data related to pathology reports and lesion locations. We also acknowledge the contributions of the research nurses (Ranita Charitra, Tracy Middleton and Irene Bell), surgeons, pathologists and theatre staff at the Royal Women's Hospital. Most importantly, we thank the endometriosis patients who generously donated their time and tissues to this research. The research was supported partly by the National Health and Medical Research Council (GNT1026033, GNT1105321).