Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?
Jess Pedrina, John Stambas
FRONTIERS IN MOLECULAR BIOSCIENCES | FRONTIERS MEDIA SA | Published : 2021
Each year, hundreds of thousands of individuals succumb to influenza virus infection and its associated complications. Several preventative and therapeutic options may be applied in order to preserve life. These traditional approaches include administration of seasonal influenza vaccines, pharmacological interventions in the form of antiviral drug therapy and supportive clinical approaches including mechanical ventilation and extracorporeal membrane oxygenation. While these measures have shown varying degrees of success, antiviral therapies and vaccination are constrained due to ongoing antigenic drift. Moreover, clinical approaches can also be associated with complications and drawbacks. Th..View full abstract
Awarded by NHMRC
NHMRC APP1158951. Grant to support a post-doctoral salary and laboratory expenses. Deakin University, Faculty of Health, provided funds for open access publication fees.