Journal article
Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis
EV Bräuner, YH Lim, T Koch, CS Uldbjerg, LS Gregersen, MK Pedersen, H Frederiksen, JH Petersen, BA Coull, AM Andersson, M Hickey, NE Skakkebæk, R Hauser, A Juul
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2021
Abstract
The incidence of many hormone-dependent diseases, including testicular cancer, has sharply increased in all high-income countries during the 20th century. This is not fully explained by established risk factors. Concurrent, increasing exposure to antiandrogenic environmental endocrine disrupting chemicals (EDCs) in fetal life may partially explain this trend. This systematic review assessed available evidence regarding the association between environmental EDC exposure and risk of testicular cancer (seminomas and nonseminomas). Following PRISMA guidelines, a search of English peer-reviewed literature published prior to December 14, 2020 in the databases PubMed and Embase® was performed. Amon..
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Awarded by National Institute of Health
Awarded by Danish Health Foundation (Helsefonden)
Awarded by Danish Health Foundation (Aase and Ejnar Danielsen)
Awarded by Danish Health Foundation (Svend Andersen Fonden)
Awarded by Danish Health Foundation (Familien Erichsens Mindefond)
Awarded by Danish Cancer Research Association (Kraeftens Bekaempelse)
Awarded by Danish Environmental Protection Agency (Miljostyrelsen)
Awarded by NHMRC Practitioner Fellowship
Funding Acknowledgements
The salaries of E.V.B., R.H., B.A.C., A.J., C.S. U., A-M.A., and J.H.P. were partially supported by a grant from the National Institute of Health (grant no. 1R01CA23681601A1). E. V.B was also partially supported by grants from the Danish Health Foundation (Helsefonden, grant no. 18-B-0016, Aase and Ejnar Danielsen, grant no. 10-002122, Svend Andersen Fonden, grant no 81A-01 and Familien Erichsens Mindefond, grant no. 6000073). M.K.P. and T.K. were funded by a grant from the Danish Cancer Research Association (Kraeftens Bekaempelse, grant no. R204-A12636). L.S.G. is funded by a grant from the Danish Environmental Protection Agency (Miljostyrelsen, grant no. MST-611-00012). M. H. is funded by an NHMRC Practitioner Fellowship (grant no. 1193838).