Journal article

Auditory input enhances somatosensory encoding and tactile goal-directed behavior

L Godenzini, D Alwis, R Guzulaitis, S Honnuraiah, GJ Stuart, LM Palmer

NATURE COMMUNICATIONS | NATURE PORTFOLIO | Published : 2021

Abstract

The capacity of the brain to encode multiple types of sensory input is key to survival. Yet, how neurons integrate information from multiple sensory pathways and to what extent this influences behavior is largely unknown. Using two-photon Ca2+ imaging, optogenetics and electrophysiology in vivo and in vitro, we report the influence of auditory input on sensory encoding in the somatosensory cortex and show its impact on goal-directed behavior. Monosynaptic input from the auditory cortex enhanced dendritic and somatic encoding of tactile stimulation in layer 2/3 (L2/3), but not layer 5 (L5), pyramidal neurons in forepaw somatosensory cortex (S1). During a tactile-based goal-directed task, audi..

View full abstract

Grants

Awarded by NHMRC


Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function


Funding Acknowledgements

We would like to thank members of the Palmer laboratory for helpful comments on the manuscript and Dan Scott for providing the AAV1/2-muGFP GFP. This work was supported by the NHMRC (APP1086082, L.M.P. and G.J.S.; APP1063533, L.M.P.), the Sylvia and Charles Viertel Charitable Foundation (L.M.P.) and the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007).