Journal article

Temporal Trends in Neurodevelopmental Outcomes to 2 Years After Extremely Preterm Birth

Jeanie LY Cheong, Joy E Olsen, Katherine J Lee, Alicia J Spittle, Gillian F Opie, Marissa Clark, Rosemarie A Boland, Gehan Roberts, Elisha K Josev, Noni Davis, Leah M Hickey, Peter J Anderson, Lex W Doyle



Importance: Survival of infants born extremely preterm (EP) (<28 weeks' gestation) has increased since the early 1990s. It is necessary to know whether increased survival is accompanied by increased neurodevelopmental disability. Objective: To examine changes in major (ie, moderate or severe) neurodevelopmental disability and survival free of major neurodevelopmental disability at 2 years in infants born EP. Design, Setting, and Participants: Four prospective longitudinal cohort studies comprising all EP live births at 22 to 27 weeks' gestation from April 1, 2016, to March 31, 2017, and earlier eras (1991-1992, 1997, and 2005), and contemporaneous term-born controls in the state of Victoria,..

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Awarded by National Health and Medical Research Council of Australia

Awarded by Medical Research Future Fund of Australia

Funding Acknowledgements

The study was supported by grants from the National Health and Medical Research Council of Australia (Centre of Clinical Research Excellence grant 546519; Centre of Research Excellence grants 1060733 and 1153176, project grant 108702, and Career Development Fellowship 1108714 [Dr Spittle]; 1127984 [Dr Lee]; and Leadership Fellowship 1176077 [Dr Anderson]), the Medical Research Future Fund of Australia (Career Development Fellowship 1141354 [Dr Cheong]), and the Victorian Government's Operational Infrastructure Support Program.