Journal article

The modified International Society of Urological Pathology system improves concordance between biopsy and prostatectomy tumour grade

David MZB Hennes, James Sewell, Michael Kerger, Christopher M Hovens, Justin S Peters, Anthony J Costello, Andrew Ryan, Niall M Corcoran

BJU INTERNATIONAL | WILEY | Published : 2021


OBJECTIVES: To assess the concordance between biopsy and radical prostatectomy (RP) specimens using the 2005 Gleason score (GS) and the International Society of Urological Pathology (ISUP) 2014/World Health Organization 2016 modified system, accounting for the introduction of transperineal biopsy and pre-biopsy multiparametric magnetic resonance imaging (mpMRI). PATIENTS AND METHODS: Between 2002 and 2019, we identified 2431 patients with paired biopsy and RP histopathology from a prospectively recorded and maintained prostate cancer database. Biopsy specimens were graded according to the 2005 GS or ISUP 2014 modified system, according to the year of diagnosis. Multivariable logistic regress..

View full abstract