Field evaluation of the gut microbiome composition of pre-school and school-aged children in Tha Song Yang, Thailand, following oral MDA for STH infections
Katharina Stracke, Poom Adisakwattana, Suparat Phuanukoonnon, Tippayarat Yoonuan, Akkarin Poodeepiyasawat, Paron Dekumyoy, Kittipong Chaisiri, Alexandra Roth Schulze, Stephen Wilcox, Harin Karunajeewa, Rebecca J Traub, Aaron R Jex
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2021
Soil-transmitted helminths, such as roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura) and hookworms (Necator americanus and Ancylostoma spp.), are gastrointestinal parasites that occur predominantly in low- to middle-income countries worldwide and disproportionally impact children. Depending on the STH species, health status of the host and infection intensity, direct impacts of these parasites include malnutrition, anaemia, diarrhoea and physical and cognitive stunting. The indirect consequences of these infections are less well understood. Specifically, gastrointestinal infections may exert acute or chronic impacts on the natural gut microfauna, leading to increased risk o..View full abstract
Awarded by NHMRC Career Development Fellowship
This work, including the efforts of ARJ, was funded by a NHMRC Career Development Fellowship (APP1126395). KS, RJT and ARJ are supported by the Victorian State Government Operational Infrastructure Support (https://www.vic.gov.au/) and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme (https://www.nhmrc.gov.au/).HK was supported by a NHMRC Career Development Fellowship (APP1064772). KS was supported by a Melbourne Research Scholarship and the Riady Scholarship through the University of Melbourne (https://www.unimelb.edu.au/).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.