Journal article
Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila
O Gericke, RM Fowler, AM Heskes, MJ Bayly, SJ Semple, CP Ndi, D Stærk, CJ Løland, DJ Murphy, BJ Buirchell, BL Møller
Plant Journal | Published : 2021
DOI: 10.1111/tpj.15448
Abstract
Eremophila is the largest genus in the plant tribe Myoporeae (Scrophulariaceae) and exhibits incredible morphological diversity across the Australian continent. The Australian Aboriginal Peoples recognize many Eremophila species as important sources of traditional medicine, the most frequently used plant parts being the leaves. Recent phylogenetic studies have revealed complex evolutionary relationships between Eremophila and related genera in the tribe. Unique and structurally diverse metabolites, particularly diterpenoids, are also a feature of plants in this group. To assess the full dimension of the chemical space of the tribe Myoporeae, we investigated the metabolite diversity in a chem..
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Awarded by U.S. Bureau of Land Management
Funding Acknowledgements
This work was supported by the VILLUM Center for Plant Plasticity (VKR023054) (BLM), the European Research Council Advanced Grant (ERC-2012-ADG 20120314) (BLM), the Lundbeck Foundation (R223-2016-85, 'Brewing diterpenoids'), the Cybec Foundation (Jim Ross Scholarship), and the Novo Nordisk Foundation Interdisciplinary Synergy (NNF 16OC0021616, 'Desert-loving therapeutics') and Distinguished Investigator 2019 (NNF 0054563, 'The Black Holes in the Plant Universe') programs (BLM). We would like to thank Tanja Schuster for specimen collections and Bob Chinnock and Ron and Claire Dadd for access to their private garden collections. We thank the Australian National Botanic Garden, Canberra, the Australian Arid Lands Botanic Garden, Port Augusta, and the National Tropical Botanic Garden, Kauai for collection of garden specimens. We thank Elizabeth H. J. Neilson (UCPH, Denmark) for initiating the chemical profiling work of Eremophila species, Madeleine Ernst (SSI, Denmark) for the advice regarding molecular networking tools, Yong Zhao (UCPH, Denmark) and Laura Mik~el Mc Nair (UCPH, Denmark) for providing reference compounds to establish the in-house spectral library, and Dominik Merges (BiK-F, Frankfurt) and the PLEN R-club for additional advice regarding multivariate statistics.