Journal article

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini

ELIFE | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2021

Abstract

Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. The first class of plant DHDPS inhibitors with micromolar potency against Arabidopsis thaliana DHDPS was identified using a high-throughput chemical screen. We determined that this class of inhibitors binds to a novel and unexplored pocket within DHDPS, which is highly conserved across plant species. The inhibitors also attenuated the..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by Perugini Australian Research Council


Funding Acknowledgements

National Health and Medical Research Council of Australia APP1091976 Tatiana P Soares da Costa Australian Research Council DE190100806 Tatiana P Soares da Costa Australian Research Council DP150103313 Santosh Panjikar Matthew A Perugini Australian Research Council IH180100006 Anthony R Gendall The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.