Refining diagnostic criteria for paediatric bronchiectasis using low-dose CT scan

Johnny Wu; Jennifer Bracken; Adrienne Lam; Kate L Francis; Fiona Ramanauskas; Anne B Chang; Phil Robinson; Paul McCallum; Danielle F Wurzel

Journal article

Refining diagnostic criteria for paediatric bronchiectasis using low-dose CT scan

Johnny Wu, Jennifer Bracken, Adrienne Lam, Kate L Francis, Fiona Ramanauskas, Anne B Chang, Phil Robinson, Paul McCallum, Danielle F Wurzel

RESPIRATORY MEDICINE | W B SAUNDERS CO LTD | Published : 2021

DOI: 10.1016/j.rmed.2021.106547

Abstract

BACKGROUND: There is a current lack of consensus amongst paediatric radiologists and respiratory paediatricians as to the correct CT definition of bronchiectasis in children. Using contemporary low-dose CT, our objectives were to determine the upper limit of normal for broncho-arterial ratio (BAR) in children and to evaluate the effect of age and general anaesthesia. METHODS: Measurements of 330 broncho-arterial ratios from 51 children (0-19 years) undergoing low-dose CT chest for non-respiratory indications were performed by 3 blinded observers (two radiologists, one respiratory physician) using four different methods. Inter-observer reliability, mean BAR and reference ranges (mean±2SD) wer..

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University of Melbourne Researchers

Danielle Wurzel Author Melbourne School of Population and Global Health

Grants

Awarded by National Health and Medical Research Council (NHMRC) Practitioner Fellowship

Awarded by Queensland Children's Hospital Foundation

Funding Acknowledgements

DFW receives research salary support from MCRI. AC is supported by a National Health and Medical Research Council (NHMRC) Practitioner Fellowship (APP1058213) and a top-up fellowship from the Queensland Children's Hospital Foundation (grant 50286). She has received multiple peer reviewed competitive grants from the NHMRC relating to bronchiectasis including a Centre of Research Excellence Grant.