Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure

LC Booth; RAU De Silva; RB Pontes; ST Yao; SG Hood; YR Lankadeva; J Kosaka; N Eikelis; GW Lambert; MP Schlaich; CN May

Journal article

Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure

LC Booth, RAU De Silva, RB Pontes, ST Yao, SG Hood, YR Lankadeva, J Kosaka, N Eikelis, GW Lambert, MP Schlaich, CN May

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

DOI: 10.1161/HYPERTENSIONAHA.120.16054

Abstract

A growing number of clinical studies suggest that in heart failure renal denervation (RDN) has beneficial effects on the autonomic control of the heart. There is also experimental evidence that surgical RDN improves sodium handling and clearance in heart failure. The aim of this study was to determine the effects of catheter-based RDN on the sympathetic and parasympathetic control of the heart, and salt and water handling capacity of the kidneys, in sheep with established heart failure. A randomized, controlled study was conducted in 10 sheep with heart failure (ejection fraction<40%) induced by rapid ventricular pacing. Sheep underwent either bilateral RDN using the Symplicity denervation s..

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University of Melbourne Researchers

Lindsea Booth Author

Song Yao Author

Yugeesh Lankadeva Author

Clive May Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) (1128108) and the Victorian Government's Operational Infrastructure Support Program. L.C. Booth was supported by an NHMRC Early Career Fellowship (1054619). R.B.P was supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes; 99999.007332/2015-07 BEX). S.T. Yao is an Australian Research Council Future Fellow (Ref: FT170100363). Y.R. Lankadeva is a National Heart Foundation of Australia Future Leader Post-doctoral Fellow (NHF, 101853) and M.P. Schlaich is supported by an NHMRC Research Fellowship.