Journal article

BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall

Luke John Ney, Allison Matthews, Emma Nicholson, Daniel Zuj, Chia Ming Ken Hsu, Trevor Steward, Bronwyn Graham, Ben Harrison, David Nichols, Kim Felmingham

BEHAVIOUR RESEARCH AND THERAPY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence the consolidation of fear extinction memories. No previous human study has tested the effect of unstimulated BDNF on fear extinction recall, and no study has tested the association between plasma BDNF levels and psychophysiological responding during an extinction paradigm. We tested the association between fear responses during a 2-day differential conditioning, extinction and extinction recall paradigm and Val66Met genotype in a group of healthy participants (N = 191). There were no group differences during habituation or acquisition. Met allele carriers compared to Val homozygotes..

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Grants

Awarded by NHMRC


Funding Acknowledgements

This work was supported by and an NHMRC Program grant to KF (APP1073041). We would like to thank Prof Rick Richardson for his generous feedback in preparing our manuscript. We would also like to thank Hannah Robert-Tissot and Claudia Payne who assisted in participant recruitment during the study.