The maternal gut microbiome during pregnancy and offspring allergy and asthma
Yuan Gao, Ralph Nanan, Laurence Macia, Jian Tan, Luba Sominsky, Thomas P Quinn, Martin O'Hely, Anne-Louise Ponsonby, Mimi LK Tang, Fiona Collier, Deborah H Strickland, Poshmaal Dhar, Susanne Brix, Simon Phipps, Peter D Sly, Sarath Ranganathan, Jakob Stokholm, Karsten Kristiansen, Lawrence EK Gray, Peter Vuillermin
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2021
Environmental exposures during pregnancy that alter both the maternal gut microbiome and the infant's risk of allergic disease and asthma include a traditional farm environment and consumption of unpasteurized cow's milk, antibiotic use, dietary fiber, and psychosocial stress. Multiple mechanisms acting in concert may underpin these associations and prime the infant to acquire immune competence and homeostasis following exposure to the extrauterine environment. Cellular and metabolic products of the maternal gut microbiome can promote the expression of microbial pattern recognition receptors, as well as thymic and bone marrow hematopoiesis relevant to regulatory immunity. At birth, transmiss..View full abstract
Awarded by National Health and Medical Research Council of Australia
Supported by National Health and Medical Research Council of Australia grants 1082307; 1147980; 1134812; 1166319.