Journal article
Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra-high risk for psychosis
TD Kristensen, LB Glenthøj, K Ambrosen, W Syeda, JM Ragahava, K Krakauer, C Wenneberg, B Fagerlund, C Pantelis, BY Glenthøj, M Nordentoft, BH Ebdrup
Acta Psychiatrica Scandinavica | WILEY | Published : 2021
DOI: 10.1111/acps.13355
Abstract
Objective: Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of these findings are unclear. Here, we applied a multivariate statistical model to examine the predictive accuracy of global white matter fractional anisotropy (FA) for transition to psychosis in individuals at ultra-high risk for psychosis (UHR). Methods: 110 UHR individuals underwent 3 Tesla diffusion-weighted imaging and clinical assessments at baseline, and after 6 and 12 months. Using logistic regression, we examined the reliability of global FA at baseline as a predictor for psychosis transition after 12 months. We tested the predictive accuracy, sensitivity and ..
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Awarded by Natur og Univers, Det Frie Forskningsråd
Funding Acknowledgements
Research Fund of the Capital Region of Denmark; Mental Health Services in the Capital Region of Denmark; TrygFonden, Grant/Award Number: ID 108119; The Danish Council for Independent Research, Grant/Award Number: DFF-4004-00314; NHMRC L3 Investigator Grant for CP, Grant/Award Number: 1196508; National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship for CP, Grant/Award Number: 1105825; Lundbeck Foundation grant for BHE, Grant/Award Number: R316-2019-191; Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Grant/Award Number: R155-2013-16337; Lundbeck Foundation for CP, Grant/Award Number: ID: R246-2016-3237