Journal article

Glioma.

Michael Weller, Wolfgang Wick, Ken Aldape, Michael Brada, Mitchell Berger, Stefan M Pfister, Ryo Nishikawa, Mark Rosenthal, Patrick Y Wen, Roger Stupp, Guido Reifenberger

Nat Rev Dis Primers | Published : 2015

Abstract

Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I-IV, which indicate different degrees of malignancy. Tremendous progress in genomic, transcriptomic and epigenetic profiling has resulted in new concepts of classifying and treating gliomas. Diffusely infiltrating gliomas in adults are now separated into three overarching tumour groups with distinct natural histories, responses to treatment and outcomes: isocitrate dehydrogenase (IDH)-mutant, 1p/19q co-deleted tumours with mostl..

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