Journal article

Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer.

Susan Halabi, William Kevin Kelly, Hua Ma, Haojin Zhou, Nicole C Solomon, Karim Fizazi, Catherine M Tangen, Mark Rosenthal, Daniel P Petrylak, Maha Hussain, Nicholas J Vogelzang, Ian M Thompson, Kim N Chi, Johann de Bono, Andrew J Armstrong, Mario A Eisenberger, Abderrahim Fandi, Shaoyi Li, John C Araujo, Christopher J Logothetis Show all

J Clin Oncol | Published : 2016

Abstract

PURPOSE: Reports have suggested that metastatic site is an important predictor of overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC), but these were based on a limited number of patients. We investigate the impact of site of metastases on OS of a substantial sample of men with mCRPC who received docetaxel chemotherapy in nine phase III trials. PATIENTS AND METHODS: Individual patient data from 8,820 men with mCRPC enrolled onto nine phase III trials were combined. Site of metastases was categorized as lymph node (LN) only, bone with or without LN (with no visceral metastases), any lung metastases (but no liver), and any liver metastases. RESULTS: Most p..

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