Assessing methamphetamine-related cue reactivity in people with methamphetamine use disorder relative to controls
Alexandre A Guerin, Katherine D Drummond, Yvonne Bonomo, Andrew J Lawrence, Susan L Rossell, Jee Hyun Kim
ADDICTIVE BEHAVIORS | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021
Methamphetamine use disorder involves methamphetamine-related cues invoking intense craving leading to relapse. Such cue reactivity is thought to arise from Pavlovian conditioning that occurs during the drug-taking experience. Cue reactivity then should be selective to methamphetamine cues (and not other cues), and not observed in people who have never experienced methamphetamine. However, these premises have never been tested and reported using objective measures such as skin conductance response (SCR). The primary aim of this study was to test these premises using a cue reactivity paradigm we developed using control cues. The secondary aim was to explore the relationship between cue reacti..View full abstract
Awarded by NHMRC
This work was supported by Melbourne Research Scholarship fromthe University of Melbourne (AAG) ; Research Training Program Schol-arship from the Australian Government (KDD) ; NHMRC Principal Research Fellowship 1116930 (AJL) ; NHMRC Senior Research Fellow-ship 1154651 (SLR) ; and NHMRC Career Development Fellowship 1083309 (JHK) . We also acknowledge the Victorian State Government Operational Infrastructure Scheme. We would like to thank the staff at Department of Addiction Medicine and De Paul House, St Vincent's Hospital Melbourne. We would like to thank Hannah Savage for dis- cussions on the quantification of skin conductance response.