Journal article

Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model.

Lena Batoon, Susan M Millard, Liza J Raggatt, Andy C Wu, Simranpreet Kaur, Lucas WH Sun, Kyle Williams, Cheyenne Sandrock, Pei Ying Ng, Katharine M Irvine, Michal Bartnikowski, Vaida Glatt, Nathan J Pavlos, Allison R Pettit

J Bone Miner Res | Published : 2021

Abstract

Osteal macrophages (osteomacs) support osteoblast function and promote bone anabolism, but their contribution to osteoporosis has not been explored. Although mouse ovariectomy (OVX) models have been repeatedly used, variation in strain, experimental design and assessment modalities have contributed to no single model being confirmed as comprehensively replicating the full gamut of osteoporosis pathological manifestations. We validated an OVX model in adult C3H/HeJ mice and demonstrated that it presents with human postmenopausal osteoporosis features with reduced bone volume in axial and appendicular bone and bone loss in both trabecular and cortical bone including increased cortical porosity..

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Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council