Journal article

Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia

Danielle J Ingle, Rebecca L Ambrose, Sarah L Baines, Sebastian Duchene, Anders Goncalves da Silva, Darren YJ Lee, Miriam Jones, Mary Valcanis, George Taiaroa, Susan A Ballard, Martyn D Kirk, Benjamin P Howden, Jaclyn S Pearson, Deborah A Williamson

NATURE COMMUNICATIONS | NATURE PORTFOLIO | Published : 2021

Abstract

Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of multidrug resistant salmonellosis. We used Bayesian phylodynamics, genomic epidemiology, and phenotypic characterization to describe the emergence and evolution of Salmonella 4,[5],12:i:- in Australia. We show that the interruption of the genetic region surrounding the phase II flagellin, FljB, causing a monophasic phenotype, represents a stepwise evolutionary event through the accumulation of mobile resistance elements with minimal impairment to bacterial fitness. We identify three lineages with different population dynamics and discrete ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia Project Grant


Awarded by NHMRC Investigator Grant


Awarded by ARC


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC), Australia Project Grant (APP1129770). D.J.I. is supported by an NHMRC Investigator Grant (APP1195210). S.D. was funded by the ARC (DE190100805). M.D.K. is supported by an NHMRC Career Development Fellowship (APP1145997). B.P.H. is supported by an NHMRC Investigator Grant (APP1196103). J.S.P. is supported by an NHMRC Career Development Fellowship (APP1159230). D.A.W. is supported by an NHMRC Investigator Grant (APP1174555). The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Department of Health and Human Services, Victoria.