Characterization of Skeletal Phenotype and Associated Mechanisms With Chronic Intestinal Inflammation in the Winnie Mouse Model of Spontaneous Chronic Colitis.
Ahmed Al Saedi, Shilpa Sharma, Ebrahim Bani Hassan, Lulu Chen, Ali Ghasem-Zadeh, Majid Hassanzadeganroudsari, Jonathan H Gooi, Rhian Stavely, Rajaraman Eri, Dengshun Miao, Kulmira Nurgali, Gustavo Duque
Inflamm Bowel Dis | Published : 2021
BACKGROUND: Osteoporosis is a common extraintestinal manifestation of inflammatory bowel disease (IBD). However, studies have been scarce, mainly because of the lack of an appropriate animal model of colitis-associated bone loss. In this study, we aimed to decipher skeletal manifestations in the Winnie mouse model of spontaneous chronic colitis, which carries a MUC2 gene mutation and closely replicates ulcerative colitis. In our study, Winnie mice, prior to the colitis onset at 6 weeks old and progression at 14 and 24 weeks old, were compared with age-matched C57BL/6 controls. We studied several possible mechanisms involved in colitis-associated bone loss. METHODS: We assessed for bone quali..View full abstract