Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia
Natalie K Binder, Teresa M MacDonald, Sally A Beard, Natasha de Alwis, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
JOURNAL OF CLINICAL MEDICINE | MDPI | Published : 2021
Despite significant maternal and fetal morbidity, a treatment for preeclampsia currently remains an unmet need in clinical care. As too does the lifelong cardiovascular risks imparted on preeclampsia sufferers. Endothelial dysfunction and end-organ injury are synonymous with both preeclampsia and cardiovascular disease, including heart failure. We propose that beta-blockers, known to improve endothelial dysfunction in the treatment of cardiovascular disease, and specifically known to reduce mortality in the treatment of heart failure, may be beneficial in the treatment of preeclampsia. Here, we assessed whether the beta-blockers carvedilol, bisoprolol, and metoprolol could quench the release..View full abstract
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Awarded by NHMRC
The NHMRC provided salary support (T.J.K.-L.; #1159261, S.T.; #1136418, and N.J.H.; #1146128). The funders had no role in study design, data collection, analysis, or decision to publish.