Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker
Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Emerson Keenan, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Jenny Myers, Catherine Cluver, Roxanne Hastie, Lina Bergman, Damanpreet Garcha, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Richard Hiscock, Natasha Pritchard, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino
JOURNAL OF THE AMERICAN HEART ASSOCIATION | WILEY | Published : 2021
Background We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly expressed in placenta, to predict preeclampsia. Methods and Results In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF-15 at 36 weeks' gestation were significantly increased among those who developed preeclampsia (P<0.001), area under the receiver operating characteristic curves (AUC) of 0.66 and 0.71, respectively. In cohort 2 a ratio of sFlt-1/PlGF (a clinical biomarker for preeclampsia) had a sensitivity of 61.0% at 83.2% specificity to predict t..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by National Health and Medical Research Council Fellowships
Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854, #116071), the Norman Beischer Medical Research Foundation; Australian Government Research Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to MacDonald; National Health and Medical Research Council Fellowships to Kaitu'u--Lino (#1159261), Hannan (#1146128), and Tong (#1136418). The funders played no role in study design or analysis.