Journal article

Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

Alexandra J Roth-Schulze, Megan AS Penno, Katrina M Ngui, Helena Oakey, Esther Bandala-Sanchez, Alannah D Smith, Theo R Allnutt, Rebecca L Thomson, Peter J Vuillermin, Maria E Craig, William D Rawlinson, Elizabeth A Davis, Mark Harris, Georgia Soldatos, Peter G Colman, John M Wentworth, Aveni Haynes, Simon C Barry, Richard O Sinnott, Grant Morahan Show all

MICROBIOME | BMC | Published : 2021

Abstract

BACKGROUND: The gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnancy is a natural life event that involves major physiological adaptation yet studies of the microbiome in pregnancy are limited and their findings inconsistent. Pregnancy with type 1 diabetes (T1D) is associated with increased maternal and fetal risks but the gut microbiome in this context has not been characterized. By whole metagenome sequencing (WMS), we defined the taxonomic composition and function of the gut bacterial microbiome across 70 pregnancies, 36 in women with T1D. RESULTS: Women with and without T1D exhibited compositional and functional changes in t..

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Grants

Awarded by Leona M. and Harry B. Helmsley Charitable Trust


Awarded by National Health and Medical Research Council of Australia (NHMRC) Centre of Research Excellence for the Protection of Pancreatic Beta Cells


Awarded by JDRF International


Awarded by NHMRC


Funding Acknowledgements

This research was supported by JDRF Australia, the recipient of the Commonwealth of Australia grant for Accelerated Research under the Medical Research Future Fund and with funding from the Leona M. and Harry B. Helmsley Charitable Trust (grant key 3-SRA-2020-966-M-N). In addition, support was provided by The National Health and Medical Research Council of Australia (NHMRC) Centre of Research Excellence for the Protection of Pancreatic Beta Cells (1078106), and JDRF International (1-SRA-2018543-S-B). Additional support was provided by a NHMRC Program Grant (LCH 1037321), Victorian State Government Operational Infrastructure Support, Diabetes South Australia and the NHMRC Research Institute Infrastructure Support Scheme. MEC was supported by a NHMRC Practitioner Fellowship (1136735), ATP by an NHMRC Senior Research Fellowship (1116955) and LCH by a NHMRC Senior Principal Research Fellowship (1080887).