Industry Viable Electrochemical DNA Detection Sensor Architecture Via a Stem-Loop Methylene Blue Redox Reporter and Rapid in Situ Probe Mobilization Method

Abstract

Pharmacogenomics is one of the endeavours in the modern acute health care sector due to the complexity of the drug reactions associated with the patients' genetic markers[1]. Therefore, the availability of patient pharmacogenetic marker testing at the point-of-care (POC) setting will help the clinicians to prescribe and personalize the medication to ensure maximum efficiency with minimal adverse drug reactions (ADR). In this regard, we focused on developing a HLA-B*15:02 pharmacogenetic biomarker testing known to cause specific ADRs for Carbamazepine[2]. In this study, disposable screen-printed electrodes (SPE) as the planar sensor surfaces and a sequence-specific stem-loop pr..