Journal article

The role of exhaustion in CAR T cell therapy.

Greg M Delgoffe, Chenqi Xu, Crystal L Mackall, Michael R Green, Stephen Gottschalk, Daniel E Speiser, Dietmar Zehn, Paul A Beavis

Cancer Cell | Published : 2021

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

Grants

Awarded by National Breast Cancer Foundation