Journal article

Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein

Priyanka Chaurasia, Thi HO Nguyen, Louise C Rowntree, Jennifer A Juno, Adam K Wheatley, Stephen J Kent, Katherine Kedzierska, Jamie Rossjohn, Jan Petersen

JOURNAL OF BIOLOGICAL CHEMISTRY | ELSEVIER | Published : 2021

Abstract

CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although numerous SARS-CoV-2 CD8+ T cell epitopes have been identified, the molecular basis underpinning T cell receptor (TCR) recognition of SARS-CoV-2-specific T cells remains unknown. The T cell response directed toward SARS-CoV-2 spike protein-derived S269-277 peptide presented by the human leukocyte antigen (HLA)-A∗02:01 allomorph (hereafter the HLA-A2S269-277 epitope) is, to date, the most immunodominant SARS-CoV-2 epitope found in individuals bearing this allele. As HLA-A2S269-277-specific CD8+ T cells utilize biased TRAV12 gene usage within t..

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Grants

Awarded by NHMRC Leadership Investigator Grant


Awarded by NHMRC Emerging Leadership Level 1 Investigator Grant


Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China


Awarded by Emerging Leadership 1 Investigator Grant


Awarded by NHMRC Early Career Fellowship (ECF)


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by MRFF Award


Funding Acknowledgements

This work was supported by the NHMRC Leadership Investigator Grant to K. K. (1173871), NHMRC Emerging Leadership Level 1 Investigator Grant to T. H. O. N. (#1194036), Research Grants Council of the Hong Kong Special Administrative Region, China (#T11-712/19-N) to K. K., and MRFF Award (#2005544) to K. K., S. J. K., A. K. W., and J. A. J. A. K. W. are supported by Emerging Leadership 1 Investigator Grant (#1173433), J. A. J. by an NHMRC Early Career Fellowship (ECF) (#1123673), and S. J. K. by NHMRC Senior Principal Research Fellowship (#1136322). J. R. is supported by an ARC Laureate fellowship.