Journal article

Is neoadjuvant therapy an alternative strategy to immediate surgery in locally perforated colon cancer?

Joseph C Kong, Jordan Lee, Rathin Gosavi, Samuel Y Ngan, Matthew M Tillman, Brian K Bednarski, Alexander G Heriot, George J Chang, Satish K Warrier



BACKGROUND: Perforations are a rare but serious complication of colorectal cancer. The current standard of treatment is emergent surgery followed by adjuvant chemotherapy. The concern with this approach is not only the uncertainty of achieving a R0 resection but also potential injury to adjacent vessels, nerves and ureters due to inflamed tissue planes. A subset of this patient population with a contained perforation who are clinically stable may have superior oncological outcomes with local sepsis control, neoadjuvant therapy followed by radical resection. The aim of this study is to report on the pre-operative safety profile for neoadjuvant therapy in the setting of an abscess from colon c..

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