Journal article

Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

Matthew S Parsons, Anne B Kristensen, Kevin J Selva, Wen Shi Lee, Thakshila Amarasena, Robyn Esterbauer, Adam K Wheatley, Benjamin R Bavinton, Anthony D Kelleher, Andrew E Grulich, Georges Khoury, Jennifer A Juno, Stephen J Kent

EBIOMEDICINE | ELSEVIER | Published : 2021

Abstract

BACKGROUND: HIV-1 infections occur following viral exposure at anogenital mucosal surfaces in the presence of semen. Semen contains immunosuppressive and pro-inflammatory factors. Semen from HIV-1-infected donors contains anti-HIV-1 antibodies. We assessed if passively infused anti-HIV-1 neutralizing antibody conferred protection from rectal SHIVSF162P3 challenge at semen exposed mucosae. METHODS: We pooled seminal plasma from HIV-1-infected donors. The pool was screened by ELISA for antibodies against HIV-1SF162 gp140. The ability of seminal plasma to inhibit macaque NK cells from responding to direct and antibody-dependent stimulation was assessed. The ability of seminal plasma to inhibit ..

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