Journal article

Is resistance to targeted therapy in cancer inevitable?

Lorey K Smith, Karen E Sheppard, Grant A McArthur

CANCER CELL | CELL PRESS | Published : 2021

Abstract

Resistance to targeted therapies is a major challenge in cancer care and occurs via genetic and non-genetic mechanisms. In this issue of Cancer Cell, Marin-Bejar et al. demonstrate that melanomas recurrently select genetic or non-genetic resistance trajectories and that targeting neural crest stem cell-like cells prevents non-genetic, but not genetic, resistance.