Higher Anti-tumor Necrosis Factor-α Levels Correlate With Improved Radiological Outcomes in Crohn's Perianal Fistulas.
Michael De Gregorio, Tanya Lee, Krupa Krishnaprasad, Gregory Amos, Yoon-Kyo An, Matthew Bastian-Jordan, Jakob Begun, Nira Borok, Dougal JM Brown, Wa Cheung, Susan J Connor, Jan Gerstenmaier, Lauren E Gilbert, Robert Gilmore, Bonita Gu, Numan Kutaiba, Allan Lee, Gillian Mahy, Ashish Srinivasan, Lena Thin Show all
Clin Gastroenterol Hepatol | Elsevier BV | Published : 2021
BACKGROUND & AIMS: Higher anti-tumor necrosis factor-α (TNF) drug levels are associated with improved clinical healing of Crohn's perianal fistulas. It is unclear whether this leads to improved healing on radiologic assessment. We aimed to evaluate the association between anti-TNF drug levels and radiologic outcomes in perianal fistulising Crohn's disease. METHODS: A cross-sectional retrospective multicenter study was undertaken. Patients with perianal fistulising Crohn's disease on maintenance infliximab or adalimumab, with drug levels within 6 months of perianal magnetic resonance imaging were included. Patients receiving dose changes or fistula surgery between drug level and imaging were ..View full abstract