Cellular Interactions with Lubricin and Hyaluronic Acid-Lubricin Composite Coatings on Gold Electrodes in Passive and Electrically Stimulated Environments
Natalie Szin, Saimon M Silva, Simon E Moulton, Robert M Kapsa, Anita F Quigley, George W Greene
ACS BIOMATERIALS SCIENCE & ENGINEERING | AMER CHEMICAL SOC | Published : 2021
In the field of bionics, the long-term effectiveness of implantable bionic interfaces depends upon maintaining a "clean" and unfouled electrical interface with biological tissues. Lubricin (LUB) is an innately biocompatible glycoprotein with impressive antifouling properties. Unlike traditional antiadhesive coatings, LUB coatings do not passivate electrode surfaces, giving LUB coatings great potential for controlling surface fouling of implantable electrode interfaces. This study characterizes the antifouling properties of bovine native LUB (N-LUB), recombinant human LUB (R-LUB), hyaluronic acid (HA), and composite coatings of HA and R-LUB (HA/R-LUB) on gold electrodes against human primary ..View full abstract
Awarded by Australian Research Discovery Project
All research conducted and published in this article was supported by Deakin University, Institute for Frontier Materials, St. Vincent's Hospital. Funding was provided by Higher Degrees by Research, Deakin University and Australian Research Discovery Project grant (DP 180102287). The authors graciously thank Lubris Biopharma who supported this work through a donation of their recombinant lubricin materials. The authors would also like to thank Dr. Noelene Quinsey from Monash University for her invaluable assistance with the purification of N-LUB materials.