Journal article

Association Between Prenatal Exposure to Antipsychotics and Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Preterm Birth, and Small for Gestational Age

Zixuan Wang, Adrienne YL Chan, David Coghill, Patrick Ip, Wallis CY Lau, Emily Simonoff, Ruth Brauer, Li Wei, Ian CK Wong, Kenneth KC Man

JAMA INTERNAL MEDICINE | AMER MEDICAL ASSOC | Published : 2021

Abstract

Importance: The risk of birth and neurodevelopmental complications with prenatal exposure to antipsychotics is unclear. Objective: To evaluate the association between prenatal antipsychotics exposure and the risk of birth and neurodevelopmental problems. Design, Setting, and Participants: This population-based cohort study included children born between January 2001 and January 2015 with follow-up to December 2019 who were identified by the Hong Kong Clinical Data Analysis and Reporting System. Pregnancies with maternal antidepressant/lithium exposure were removed. Primary analyses compared gestationally exposed and gestationally nonexposed individuals with propensity score fine stratificati..

View full abstract

Grants

Awarded by Hong Kong Research Grant Council Collaborative Research Fund


Funding Acknowledgements

This study is supported by the CW Maplethorpe Fellowship for KKCM's Salary at UCL and a grant from the Innovation and Technology Commission of the Hong Kong Special Administration Region Government for Mrs Chan's salary at the University of Hong Kong. Data extraction in Hong Kong is funded by Hong Kong Research Grant Council Collaborative Research Fund number C7009-19G.