Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation
Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2021
Oral cancer is a major global health problem with high incidence and low survival rates. The oral cavity contains biofilms as dental plaques that harbour both Gram-negative and Gram-positive bacterial antigens, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), respectively. LPS and LTA are known to stimulate cancer cell growth, and the bioactive phytochemical capsaicin has been reported to reverse this effect. Here, we tested the efficacy of oral cancer chemotherapy treatment with capsaicin in the presence of LPS, LTA or the combination of both antigens. LPS and LTA were administered to Cal 27 oral cancer cells prior to and/or concurrently with capsaicin, and the treatment efficacy was e..View full abstract
The project was funded by the Sydney Vital Translational Cancer Research Award Round 9. Rajdeep Chakraborty is the recipient of the International Macquarie University Research Excellence Scholarship (iMQRES).