Journal article

Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males.

Tayla R Penny, Yen Pham, Amy E Sutherland, Joohyung Lee, Graham Jenkin, Michael C Fahey, Suzanne L Miller, Courtney A McDonald

Sci Rep | Published : 2021

Abstract

Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No study has investigated sexual dimorphism in the efficacy of umbilical cord blood (UCB) cell therapy. HI injury was induced in postnatal day 10 (PND10) rat pups using the Rice-Vannucci method of carotid artery ligation. Pups received 3 doses of UCB cells (PND11, 13, 20) and underwent behavioural testing. On PND50, brains were collected for immunohistochemical analysis. Behavioural and neuropathological outcomes were assessed for sex differences. HI brain injury resulted in a significant dec..

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Grants

Awarded by National Health and Medical Research Council