Journal article

Neighborhood disadvantage and longitudinal brain-predicted-age trajectory during adolescence

Divyangana Rakesh, Vanessa Cropley, Andrew Zalesky, Nandita Vijayakumar, Nicholas B Allen, Sarah Whittle



Neighborhood disadvantage has consistently been linked to alterations in brain structure; however, positive environmental (e.g., positive parenting) and psychological factors (e.g., temperament) may buffer these effects. We aimed to investigate associations between neighborhood disadvantage and deviations from typical neurodevelopmental trajectories during adolescence, and examine the moderating role of positive parenting and temperamental effortful control (EC). Using a large dataset (n = 1313), a normative model of brain morphology was established, which was then used to predict the age of youth from a longitudinal dataset (n = 166, three time-points at age 12, 16, and 19). Using linear mi..

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Awarded by National Health and Medical Research Council (NHMRC) Investigator Grant

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

DR was supported by a Melbourne Research Scholarship (MRS) , VC was supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (1177370) , AZ was supported by an NHMRC Senior Research Fellowship (ID: 1136649) , SW was supported by an NHMRC Career Development Fellowship (ID: 1125504) . The Philadelphia Neurodevelopment Cohort sample is a publicly available data set. Support for the collection of the data sets was pro-vided by grant RC2MH089983 awarded to Raquel Gur and RC2MH089924 awarded to Hakon Hakonarson. All subjects were recruited through the Center for Applied Genomics at The Children's Hospital in Philadelphia. Database of Genotypes and Phenotypes study afccession: phs000607.v2.p2