Journal article

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

Gabriela Sycz, Gisela Di Venanzio, Jesus S Distel, Mariana G Sartorio, Nguyen-Hung Le, Nichollas E Scott, Wandy L Beatty, Mario F Feldman

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2021

Abstract

Multidrug-resistant Acinetobacter baumannii infections are increasing at alarming rates. Therefore, novel antibiotic-sparing treatments to combat these A. baumannii infections are urgently needed. The development of these interventions would benefit from a better understanding of this bacterium's pathobiology, which remains poorly understood. A. baumannii is regarded as an extracellular opportunistic pathogen. However, research on Acinetobacter has largely focused on common lab strains, such as ATCC 19606, that have been isolated several decades ago. These strains exhibit reduced virulence when compared to recently isolated clinical strains. In this work, we demonstrate that, unlike ATCC 196..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases


Funding Acknowledgements

MFF was supported by grants from the National Institute of Allergy and Infectious Diseases (grant R01AI144120). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.