Journal article

Use of feline herpesvirus as a vaccine vector offers alternative applications for feline health

Ellen Cottingham, Thurid Johnstone, A Carol Hartley, M Joanne Devlin

VETERINARY MICROBIOLOGY | ELSEVIER | Published : 2021

Abstract

Herpesviruses are attractive vaccine vector candidates due to their large double stranded DNA genome and latency characteristics. Within the scope of veterinary vaccines, herpesvirus-vectored vaccines have been well studied and commercially available vectored vaccines are used to help prevent diseases in different animal species. Felid alphaherpesvirus 1 (FHV-1) has been characterised as a vector candidate to protect against a range of feline pathogens. In this review we highlight the methods used to construct FHV-1 based vaccines and their outcomes, while also proposing alternative uses for FHV-1 as a viral vector.