Journal article
Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits
LF Rizzardi, PF Hickey, A Idrizi, R Tryggvadóttir, CM Callahan, KE Stephens, SD Taverna, H Zhang, S Ramazanoglu, KD Hansen, AP Feinberg
Genome Biology | Published : 2021
Abstract
Background: DNA methylation dynamics in the brain are associated with normal development and neuropsychiatric disease and differ across functionally distinct brain regions. Previous studies of genome-wide methylation differences among human brain regions focus on limited numbers of individuals and one to two brain regions. Results: Using GTEx samples, we generate a resource of DNA methylation in purified neuronal nuclei from 8 brain regions as well as lung and thyroid tissues from 12 to 23 donors. We identify differentially methylated regions between brain regions among neuronal nuclei in both CpG (181,146) and non-CpG (264,868) contexts, few of which were unique to a single pairwise compari..
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Awarded by National Institutes of Health
Funding Acknowledgements
The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The work performed here was supported by NIH Grant U01MH104393 (A.P.F.). The Flow Cytometry Cell Sorting Core Facility at Johns Hopkins School of Public Health was supported by CFAR: 5P30AI094189-04, 1S10OD016315-01, and 1S10RR13777001.