Journal article
Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magnetic Resonance Imaging Protocol and SARS-CoV-2–Induced Changes for a Randomized Double-blind Controlled Trial
S Pszczolkowski, WJ Cottam, PM Briley, SJ Iwabuchi, C Kaylor-Hughes, A Shalabi, B Babourina-Brooks, A Berrington, S Barber, ASD Paola, A Blamire, RH McAllister-Williams, J Parikh, M Abdelghani, L Matthäus, R Hauffe, P Liddle, DP Auer, R Morriss
Jmir Research Protocols | JMIR PUBLICATIONS, INC | Published : 2022
DOI: 10.2196/31925
Abstract
Background: Depression is a substantial health and economic burden. In approximately one-third of patients, depression is resistant to first-line treatment; therefore, it is essential to find alternative treatments. Transcranial magnetic stimulation (TMS) is a neuromodulatory treatment involving the application of magnetic pulses to the brain that is approved in the United Kingdom and the United States in treatment-resistant depression. This trial aims to compare the clinical effectiveness, cost-effectiveness, and mechanism of action of standard treatment repetitive TMS (rTMS) targeted at the F3 electroencephalogram site with a newer treatment—a type of TMS called theta burst stimulation (TB..
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Awarded by Manchester Biomedical Research Centre
Funding Acknowledgements
Additional support for the study was provided by the National Institute for Health Research (NIHR) Clinical Research Network East Midlands, North-East, North Cumbria, and North Thames. RM is funded in part by the Nottingham NIHR Biomedical Research Centre, NIHR Applied Research Collaboration East Midlands, NIHR MindTech Medical Technology and in-Vitro Centre, and the NIHR Senior Investigator Award. PMB is funded by the NIHR Academic Clinical Fellowship. BBB was fully, and SP was partially funded by the Nottingham NIHR Biomedical Research Centre. SJI was partially funded by the Pain Centre Versus Arthritis. Additional technical support was provided locally to set up image analysis pipelines from Stam Sotiropoulos, Alireza Mohammadinezhad Kisomi (funded by the Nottingham NIHR Biomedical Research Centre), Flora Kennedy McConnell, and Michael Chappell. This project (project reference 16/44/22) is funded by the Efficacy and Mechanism Evaluation Program, a Medical Research Council and NIHR partnership. The views expressed in this publication are those of the author or authors and not necessarily those of the Medical Research Council, NIHR, or the Department of Health and Social Care. The equipment and technical support were supplied by Magstim Ltd.