Journal article
Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination
A Daly, C Martin, J Sherriff, TA Mori, G Pereira, RM Lucas, AL Ponsonby, B Taylor, I van der Mei, LJ Black
Multiple Sclerosis and Related Disorders | Published : 2021
Abstract
Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median..
View full abstractGrants
Funding Acknowledgements
Funding for the Ausimmune Study was provided by the National MS Society of the United States of America, the National Health and Medical Research Council of Australia, and MS Research Australia. LJB is supported by an MS Research Australia Postdoctoral Fellowship and a Curtin University Research Fellowship. RML and TAM are supported by National Health and Medical Research Council of Australia Senior Research Fellowships. AD was supported by MS Western Australia (MSWA). Funding bodies had no role in the design or conduct of the study; collection, management, analysis or interpretation of data; or preparation, review or approval of the manuscript.