Automated Perfusion-Diffusion Magnetic Resonance Imaging in Childhood Arterial Ischemic Stroke
Melissa J Visser, Joseph Yuan-Mou Yang, Fernando Calamante, Michael Kean, Christopher L Adamson, Gagan Sharma, Vicki Anderson, Bruce CV Campbell, Mark T Mackay
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Background and Purpose: Recent studies using automated perfusion imaging software have identified adults most likely to benefit from reperfusion therapies in extended time windows. The time course of penumbral tissue is poorly characterized in childhood arterial ischemic stroke (AIS). We explore the feasibility of using automated perfusion-diffusion imaging software to characterize penumbra in childhood AIS. Methods: An observational cohort study of children with acute unilateral AIS presenting to our institution. Diffusion-weighted imaging and dynamic susceptibility contrast perfusion magnetic resonance imaging performed within 72 hours of symptom onset were necessary for inclusion. Perfusi..View full abstract
Awarded by Royal Children's Hospital Foundation
Dr Mackay received grant funding from Murdoch Children's Research Institute. M.J. Visser receives funding from an Australian Government Research Training Program (RTP) Scholarship. Dr Yang received positional funding from the Royal Children's Hospital Foundation (RCH 1000). The research was also supported by the Victorian Government Operational Infrastructure Fund.